Practice tips and tools for the successful use of U-500 regular human insulin: the diabetes educator is key

Diabetes Educ. Mar-Apr 2014;40(2):153-65. doi: 10.1177/0145721713508822. Epub 2013 Oct 24.


This review provides information to equip diabetes educators to instruct and guide patients in using U-500 human regular insulin (U-500R). The article includes an overview of U-500R pharmacology and clinical data, strategies for outpatient and inpatient use, and tools for patient education. U-500R is useful for treating patients with any type of diabetes who require high doses of insulin. U-500R alleviates the volume-related problems associated with high doses of U-100 insulin, making treatment with high doses of insulin more feasible (because of the need for fewer injections for patients) as well as more cost-efficient and potentially more effective. These tools can help diabetes educators feel more comfortable and confident as they advise and educate patients who receive high-dose U-500R as part of their overall diabetes care plan. The diabetes educator plays a vital role in helping patients use U-500R safely and successfully.

Publication types

  • Review

MeSH terms

  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / psychology
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / psychology
  • Directive Counseling
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Hypoglycemic Agents / pharmacokinetics
  • Hypoglycemic Agents / pharmacology
  • Injections, Subcutaneous / methods*
  • Insulin / administration & dosage
  • Insulin, Regular, Human / administration & dosage*
  • Insulin, Regular, Human / pharmacokinetics
  • Insulin, Regular, Human / pharmacology
  • Patient Education as Topic
  • Patient Satisfaction
  • Risk Factors
  • Self Care / methods*
  • Syringes / statistics & numerical data*
  • Treatment Outcome


  • Blood Glucose
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Insulin
  • Insulin, Regular, Human
  • hemoglobin A1c protein, human