This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of mitochondria-targeted antioxidants (MitoQ and SkQs). The latter compounds look promising in treating several incurable pathologies as well as aging.
Keywords: 10-(6′-plastoquinonyl) decylrhodamine 19; 10-(6′-plastoquinonyl) decyltriphenylphosphonium; 10-(6′-ubiquinonyl) decyltriphenylphosphonium; MitoQ; Mitochondria; Mitochondria-targeted antioxidants; ROS; Reactive oxygen species; Respiratory chain; SkQ1; SkQR1; SkQs; mROS; mitochondrial reactive oxygen species; plastoquinonyl conjugates with penetrating cations; reactive oxygen species; transmembrane electric potential difference; Δψ.
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