Cationic antioxidants as a powerful tool against mitochondrial oxidative stress

Biochem Biophys Res Commun. 2013 Nov 15;441(2):275-9. doi: 10.1016/j.bbrc.2013.10.063. Epub 2013 Oct 22.

Abstract

This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of mitochondria-targeted antioxidants (MitoQ and SkQs). The latter compounds look promising in treating several incurable pathologies as well as aging.

Keywords: 10-(6′-plastoquinonyl) decylrhodamine 19; 10-(6′-plastoquinonyl) decyltriphenylphosphonium; 10-(6′-ubiquinonyl) decyltriphenylphosphonium; MitoQ; Mitochondria; Mitochondria-targeted antioxidants; ROS; Reactive oxygen species; Respiratory chain; SkQ1; SkQR1; SkQs; mROS; mitochondrial reactive oxygen species; plastoquinonyl conjugates with penetrating cations; reactive oxygen species; transmembrane electric potential difference; Δψ.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Cations / pharmacology
  • Cells, Cultured
  • Humans
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Organophosphorus Compounds / pharmacology*
  • Oxidative Stress / drug effects*
  • Plastoquinone / analogs & derivatives*
  • Plastoquinone / pharmacology
  • Reactive Oxygen Species / metabolism*
  • Rhodamines / pharmacology*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology

Substances

  • 10-(6'-plastoquinonyl) decylrhodamine 19
  • 10-(6'-plastoquinonyl)decyltriphenylphosphonium
  • 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide
  • Antioxidants
  • Cations
  • Organophosphorus Compounds
  • Reactive Oxygen Species
  • Rhodamines
  • Ubiquinone
  • Plastoquinone