[Bone diseases caused by impaired glucose and lipid metabolism]

Clin Calcium. 2013 Nov;23(11):1605-11.
[Article in Japanese]


The number of patients with lifestyle-related diseases is rapidly increasing in Japan. Metabolic syndrome caused by abdominal fat accumulation induces diabetes mellitus, dyslipidemia, and hypertension, resulting in an increase in cardiovascular diseases. On the other hand, recent studies have shown that the lifestyle-related diseases are risk factors of osteoporotic fractures. Although it remains still unclear how metabolic disorders affect bone tissue, oxidative stress and/or glycation stress might directly have negative impacts on bone tissue and increase the risk of fractures. In this review, we describe the association of diabetes mellitus and dyslipidemia with the fracture risk through oxidative stress and glycation stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Diseases / etiology*
  • Bone Diseases / metabolism
  • Bone Diseases / pathology
  • Bone and Bones / metabolism
  • Bone and Bones / pathology
  • Collagen / metabolism
  • Diabetes Complications*
  • Dyslipidemias / complications*
  • Fractures, Spontaneous / etiology*
  • Glycation End Products, Advanced / adverse effects
  • Humans
  • Life Style
  • Osteoblasts / physiology
  • Osteoporosis / etiology
  • Oxidative Stress / physiology
  • Risk Factors


  • Glycation End Products, Advanced
  • Collagen