A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1

Ann Hum Genet. 1985 Jan;49(1):31-9. doi: 10.1111/j.1469-1809.1985.tb01673.x.


An antigen expressed by most human cells, but not erythrocytes, has been defined by a murine monoclonal antibody, TRA-2-10. This antigen is expressed on the surface of human-mouse somatic cell hybrids, and segregation analysis indicates that it is controlled by a gene located on human chromosome 1. From lysates of most human cells, surface-labelled with 125I, TRA-2-10 immunoprecipitates two polypeptides with molecular weights in the range of about 55 000 to 73 000 depending upon the cell line. Since the TRA-2-10 polypeptides from a fibroblast cell strain and a hepatoma cell line from one individual differ, we conclude that the observed difference in molecular weight has an epigenetic origin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal*
  • Antigens, Surface / genetics*
  • Cell Line
  • Cell Separation
  • Chromosome Mapping
  • Chromosomes, Human, 1-3*
  • Epitopes / genetics
  • Flow Cytometry
  • Humans
  • Hybridomas
  • Mice
  • Precipitin Tests
  • Radioimmunoassay


  • Antibodies, Monoclonal
  • Antigens, Surface
  • Epitopes