Direction selectivity is computed by active dendritic integration in retinal ganglion cells

Nat Neurosci. 2013 Dec;16(12):1848-56. doi: 10.1038/nn.3565. Epub 2013 Oct 27.


Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to demonstrate that active dendritic integration underlies the computation of direction selectivity in rabbit retinal ganglion cells. Direction-selective retinal ganglion cells fire action potentials in response to visual image movement in a preferred direction. Dendritic recordings revealed that preferred-direction moving-light stimuli led to dendritic spike generation in terminal dendrites, which were further integrated and amplified as they spread through the dendritic arbor to the axon to drive action potential output. In contrast, when light bars moved in a null direction, synaptic inhibition vetoed neuronal output by directly inhibiting terminal dendritic spike initiation. Active dendritic integration therefore underlies a physiologically engaged circuit-based computation in the retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology*
  • Animals
  • Dendrites / physiology*
  • Electric Stimulation
  • Female
  • GABA Antagonists / pharmacology
  • In Vitro Techniques
  • Male
  • Nerve Net / drug effects
  • Nerve Net / physiology
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Organic Chemicals / metabolism
  • Orientation / physiology*
  • Patch-Clamp Techniques
  • Photic Stimulation
  • Pyridazines / pharmacology
  • Rabbits
  • Retina / cytology
  • Retinal Ganglion Cells / cytology*
  • Sodium Channel Blockers / pharmacology
  • Tetrodotoxin / pharmacology


  • Alexa594
  • GABA Antagonists
  • Organic Chemicals
  • Pyridazines
  • Sodium Channel Blockers
  • Tetrodotoxin
  • gabazine