Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.PLoS One. 2011 Feb 24;6(2):e16616. doi: 10.1371/journal.pone.0016616. PLoS One. 2011. PMID: 21390209 Free PMC article.
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.JAMA Neurol. 2014 Nov;71(11):1394-404. doi: 10.1001/jamaneurol.2014.1491. JAMA Neurol. 2014. PMID: 25199842 Free PMC article.
Genome-wide analysis of genetic loci associated with Alzheimer disease.JAMA. 2010 May 12;303(18):1832-40. doi: 10.1001/jama.2010.574. JAMA. 2010. PMID: 20460622 Free PMC article.
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.JAMA. 2013 Apr 10;309(14):1483-92. doi: 10.1001/jama.2013.2973. JAMA. 2013. PMID: 23571587 Free PMC article.
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.Lancet Neurol. 2020 Apr;19(4):326-335. doi: 10.1016/S1474-4422(19)30435-1. Epub 2020 Jan 24. Lancet Neurol. 2020. PMID: 31986256 Review.
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TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease.Front Immunol. 2020 Apr 23;11:724. doi: 10.3389/fimmu.2020.00724. eCollection 2020. Front Immunol. 2020. PMID: 32391019 Free PMC article. Review.
Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease.Mol Neurodegener. 2020 May 7;15(1):28. doi: 10.1186/s13024-020-00377-5. Mol Neurodegener. 2020. PMID: 32381088 Free PMC article.
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