Obesity and breast cancer: role of inflammation and aromatase

Evan R Simpson; Kristy A Brown

doi:10.1530/JME-13-0217

Obesity and breast cancer: role of inflammation and aromatase

J Mol Endocrinol. 2013 Nov 26;51(3):T51-9. doi: 10.1530/JME-13-0217. Print 2013 Dec.

Authors

Evan R Simpson¹, Kristy A Brown

Affiliation

¹ Metabolism and Cancer Laboratory, Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia Departments ofBiochemistry and Molecular Biology Physiology, Monash University, Clayton, Victoria 3168, Australia.

PMID: 24163427
DOI: 10.1530/JME-13-0217

Abstract

Obesity is now recognised to be an inflammatory condition in which dysregulated metabolism plays an integral role. Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast cancer, especially in women who are obese.

Keywords: PGE2; aromatase; breast cancer; inflammation; obesity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aromatase / genetics
Aromatase / metabolism*
Breast Neoplasms / enzymology*
Breast Neoplasms / immunology*
Female
Humans
Inflammation / enzymology
Inflammation / immunology
Obesity / enzymology*
Obesity / immunology*

Substances

Aromatase