Non-adherence in difficult asthma and advances in detection

Expert Rev Respir Med. 2013 Dec;7(6):607-14. doi: 10.1586/17476348.2013.842129. Epub 2013 Oct 29.


Non-adherence to anti-inflammatory therapies is common in patients referred for specialist assessment at difficult-to-treat asthma services. In the difficult asthma setting, non-adherence to treatment is associated with poor baseline asthma control, increased frequency of exacerbations and asthma-related hospitalizations, as well as increased risk of death. Here, we present a review of the current literature surrounding the prevalence and risks of non-adherence in difficult asthma and we report on current methods of measuring treatment adherence and advances in the detection of non-adherence. We will also explore methods by which non-adherence in difficult asthma can be addressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Humans
  • Medication Adherence / statistics & numerical data*
  • Patient Compliance / statistics & numerical data*
  • Prevalence
  • Risk Factors
  • Self Report
  • Treatment Outcome


  • Anti-Asthmatic Agents