mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Nat Neurosci. 2013 Nov;16(11):1537-43. doi: 10.1038/nn.3546. Epub 2013 Oct 28.


The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Mental Disorders / complications
  • Mental Disorders / metabolism*
  • Nervous System Diseases / complications
  • Nervous System Diseases / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • TOR Serine-Threonine Kinases / genetics
  • TOR Serine-Threonine Kinases / metabolism*


  • MTOR protein, human
  • TOR Serine-Threonine Kinases