Mining the epigenetic landscape in ALL

Nat Genet. 2013 Nov;45(11):1269-70. doi: 10.1038/ng.2808.


The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromatin / genetics*
  • Female
  • Histone-Lysine N-Methyltransferase / genetics*
  • Histones / genetics*
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Repressor Proteins / genetics*


  • Chromatin
  • Histones
  • Repressor Proteins
  • Histone-Lysine N-Methyltransferase
  • NSD2 protein, human