Cell biology in neuroscience: the interplay between Hebbian and homeostatic synaptic plasticity

J Cell Biol. 2013 Oct 28;203(2):175-86. doi: 10.1083/jcb.201306030.


Synaptic plasticity, a change in the efficacy of synaptic signaling, is a key property of synaptic communication that is vital to many brain functions. Hebbian forms of long-lasting synaptic plasticity-long-term potentiation (LTP) and long-term depression (LTD)-have been well studied and are considered to be the cellular basis for particular types of memory. Recently, homeostatic synaptic plasticity, a compensatory form of synaptic strength change, has attracted attention as a cellular mechanism that counteracts changes brought about by LTP and LTD to help stabilize neuronal network activity. New findings on the cellular mechanisms and molecular players of the two forms of plasticity are uncovering the interplay between them in individual neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Homeostasis
  • Humans
  • Long-Term Potentiation
  • Long-Term Synaptic Depression
  • Nerve Net / physiology
  • Nerve Tissue Proteins / metabolism
  • Neuronal Plasticity*
  • Neurons / metabolism
  • Neurons / physiology*
  • Synapses / metabolism
  • Synapses / physiology*
  • Synaptic Transmission*


  • Nerve Tissue Proteins