Abstract
The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies.
Keywords:
Gymnema sylvestre; diabetes; metabolism; obesity.
© 2013 Society of Chemical Industry.
Publication types
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Comparative Study
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Review
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Systematic Review
MeSH terms
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Animals
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Anti-Obesity Agents / adverse effects
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / isolation & purification
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Anti-Obesity Agents / therapeutic use*
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Diabetes Mellitus, Type 2 / diet therapy
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / metabolism
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Dietary Sucrose / antagonists & inhibitors
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Dietary Sucrose / metabolism
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Dietary Supplements* / adverse effects
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Dietary Supplements* / analysis
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Gymnema sylvestre / chemistry*
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Humans
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Hypoglycemic Agents / adverse effects
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / therapeutic use*
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Intestinal Absorption / drug effects
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Lipid Metabolism / drug effects
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Lipotropic Agents / adverse effects
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Lipotropic Agents / chemistry
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Lipotropic Agents / isolation & purification
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Lipotropic Agents / therapeutic use*
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Obesity / diet therapy
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Obesity / drug therapy
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Obesity / metabolism
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Plant Extracts / adverse effects
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / therapeutic use*
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Plant Leaves / chemistry*
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Saponins / adverse effects
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Saponins / analysis
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Saponins / therapeutic use
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Solvents / chemistry
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Triterpenes / adverse effects
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Triterpenes / analysis
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Triterpenes / therapeutic use
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Weight Loss / drug effects
Substances
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Anti-Obesity Agents
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Dietary Sucrose
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Hypoglycemic Agents
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Lipotropic Agents
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Plant Extracts
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Saponins
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Solvents
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Triterpenes
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gymnemic acid