Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children

Neuropediatrics. 2013 Dec;44(6):297-301. doi: 10.1055/s-0033-1358602. Epub 2013 Oct 28.


The recent detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in acquired inflammatory demyelinating diseases, such as neuromyelitis optica, or acute disseminated encephalomyelitis, and multiple sclerosis, in children strongly indicates that B-cell-dependent mechanisms contribute to the pathogenesis. This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantibodies / metabolism*
  • Central Nervous System / metabolism*
  • Child
  • Encephalomyelitis, Acute Disseminated / immunology*
  • Encephalomyelitis, Acute Disseminated / metabolism*
  • Humans


  • Autoantibodies