Isolated hepatic perfusion for metastatic melanoma

J Surg Oncol. 2014 Mar;109(4):383-8. doi: 10.1002/jso.23474. Epub 2013 Oct 25.


Unresectable hepatic metastases from melanoma present a challenge to the physician. Although there have been advances in systemic therapies for patients with metastatic cutaneous melanoma to the liver, the overall prognosis is poor and is worse in patients with metastatic ocular melanoma. Isolated hepatic perfusion, open or percutaneous, allows high doses of cytotoxic chemotherapy to be delivered directly to the liver while minimizing systemic exposure, and has emerged as a viable treatment options for these complex patients.

Keywords: isolated hepatic perfusion; melphalan; percutaneous hepatic perfusion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Chemotherapy, Cancer, Regional Perfusion / methods*
  • Hepatic Artery
  • Humans
  • Liver Neoplasms / blood supply
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / secondary*
  • Melanoma / drug therapy*
  • Melanoma / secondary*


  • Antineoplastic Agents