The primary extra-gastrointestinal stromal tumor of pleura: a case report and a literature review

Jpn J Clin Oncol. 2013 Dec;43(12):1269-72. doi: 10.1093/jjco/hyt158. Epub 2013 Oct 29.


The gastrointestinal stromal tumor is the most common mesenchymal neoplasm of the gastrointestinal tract. The gastrointestinal stromal tumor universally expresses KIT and DOG-1 and frequently harbors oncogenic mutations in the KIT gene. While the gastrointestinal stromal tumor usually arises in the alimentary tract, it is rarely found in the extragastrointestinal area. When it is, it is called an extragastrointestinal stromal tumor. Although the pathogenesis, prognostic factors and outcomes of gastrointestinal stromal tumors are well known, those of extragastrointestinal stromal tumors have not been fully studied. We report, herein, a unique primary extragastrointestinal stromal tumor from the pleura in a 73-year-old woman who presented with pleural mass. The extragastrointestinal stromal tumor was surgically resected and confirmed by means of an immunohistochemical study and a molecular analysis.

Keywords: DOG-1; KIT; Thoracic-Mediastinum; gastrointestinal stromal tumor; pleura; pleural cavity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Female
  • Gastrointestinal Stromal Tumors / diagnosis*
  • Gastrointestinal Stromal Tumors / diagnostic imaging
  • Gastrointestinal Stromal Tumors / pathology
  • Gastrointestinal Stromal Tumors / surgery*
  • Humans
  • Pleural Neoplasms / diagnosis*
  • Pleural Neoplasms / diagnostic imaging
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / surgery*
  • Tomography, X-Ray Computed


  • Biomarkers, Tumor