Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin

J Antibiot (Tokyo). 2014 Feb;67(2):199-201. doi: 10.1038/ja.2013.110. Epub 2013 Oct 30.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacillus subtilis / drug effects
  • Drug Discovery
  • Escherichia coli / drug effects
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacterial Infections / drug therapy
  • Magnetic Resonance Imaging
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Polyenes / chemistry*
  • Polyenes / isolation & purification
  • Polyenes / pharmacology
  • Polyketide Synthases / analysis
  • Polyketide Synthases / chemistry
  • Polyketide Synthases / metabolism*
  • Streptomyces aureofaciens / enzymology
  • Streptomyces aureofaciens / metabolism*

Substances

  • Glycosides
  • Polyenes
  • alpha-lipomycin
  • Polyketide Synthases