Branch retinal vein occlusion: treatment modalities: an update of the literature

Semin Ophthalmol. 2014 Mar;29(2):85-107. doi: 10.3109/08820538.2013.833271. Epub 2013 Oct 30.


Background: Retinal vein occlusion is the second most common retinal vascular disorder after diabetic retinopathy and is considered to be an important cause of visual loss. In this review, our purpose is to update the literature about the treatment alternatives for branch retinal vein occlusion.

Methods: Eligible papers were identified by a comprehensive literature search of PubMed, using the terms "branch retinal vein occlusion," "therapy," "intervention," "treatment," "vitrectomy," "sheathotomy," "laser," "anti-VEGF," "pegaptanib," "bevacizumab," "ranibizumab," "triamcinolone," "dexamethasone," "corticosteroids," "non-steroids," "diclofenac," "hemodilution," "fibrinolysis," "tPA," and "BRVO." Additional papers were also selected from reference lists of papers identified by the electronic database search.

Results: Treatment modalities were analyzed.

Conclusions: There are several treatment modalities for branch retinal vein occlusion and specifically for its complications, such as macular edema, vitreous hemorrhage, retinal neovascularization, and retinal detachment, including anti-aggregative therapy and fibrinolysis, isovolemic hemodilution, vitrectomy with or without sheathotomy, peripheral scatter and macular grid retinal laser therapy, non-steroid agents, intravitreal steroids, and intravitreal anti-vascular endothelial growth factors (anti-VEGFs).

Publication types

  • Review

MeSH terms

  • Humans
  • Ophthalmologic Surgical Procedures*
  • Pharmaceutical Preparations*
  • Retinal Vein Occlusion / drug therapy
  • Retinal Vein Occlusion / surgery
  • Retinal Vein Occlusion / therapy*


  • Pharmaceutical Preparations