Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jan;21(1):46-50.
doi: 10.1128/CVI.00553-13. Epub 2013 Oct 30.

Antibody Response to Achromobacter Xylosoxidans During HIV Infection Is Associated With Lower CD4 Levels and Increased Lymphocyte Activation

Affiliations
Free PMC article

Antibody Response to Achromobacter Xylosoxidans During HIV Infection Is Associated With Lower CD4 Levels and Increased Lymphocyte Activation

Erick T Tatro et al. Clin Vaccine Immunol. .
Free PMC article

Abstract

Inflammation during HIV infection is associated with worse disease outcomes and progression. Many mechanisms have been indicted, including HIV itself, coinfections, and gut microbial translocation. Concerning microbial translocation, we hypothesized that adaptive immune responses to a specific bacterial species known to be present in gut-associated lymphoid tissue are higher among HIV-infected individuals than among HIV-uninfected controls and are associated with T cell activation and lower CD4 T cell counts. By characterizing the IgG response to Achromobacter xylosoxidans, we found that HIV-infected participants who were immunoresponsive (n = 48) had significantly lower CD4 percentages (P = 0.01), greater CD4 activation (percentages of RA(-) CD38(+)) (P = 0.03), and higher soluble CD14 (P = 0.01). HIV-positive individuals had higher anti-A. xylosoxidans IgG titers than HIV-uninfected individuals (P = 0.04). The results suggest an abnormal adaptive immune activation to gut microflora during HIV infection.

Figures

FIG 1
FIG 1
(A) Contingency plots showing the proportions of A. xylosoxidans-responsive individuals (y axis) in HIV-positive and -negative groups, separated by time points (x axis). The proportion of responsive individuals increases as the number of sampling visits increases in the HIV-positive group. (B) Anti-A. xylosoxidans Y0 IgG titers versus peripheral blood mononuclear cell HIV DNA (copies/106 cells), which illustrates a significant negative correlation and linear fit (Pearson R = −0.51, P = 0.008), color coded by sampling time point and natural log transformation.

Similar articles

See all similar articles

Cited by 1 article

Publication types

MeSH terms

Feedback