Biological imaging using nanoparticles of small organic molecules with fluorescence emission at wavelengths longer than 1000 nm

Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13002-6. doi: 10.1002/anie.201307346. Epub 2013 Oct 31.

Abstract

Embedded in a polymer: A hydrophobic organic molecule that fluoresces in the near-infrared II (NIR-II) region was made water-soluble and biocompatible by its embedment in a polymer nanoparticle, which was then coated with hydrophilic poly(ethylene glycol) chains. The resulting nanoparticles exhibit bright fluorescence in the NIR-II window and high photostability in aqueous media and were used for in vivo imaging in mice.

Keywords: fluorescence; imaging agents; nanoparticles; near infrared; polymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry
  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Fluorescent Dyes / chemistry*
  • Mice
  • Mice, Nude
  • Microscopy, Atomic Force
  • Nanoparticles / chemistry*
  • Phosphatidylethanolamines / chemistry
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*
  • Spectroscopy, Near-Infrared / methods*

Substances

  • Acrylic Resins
  • Biocompatible Materials
  • Fluorescent Dyes
  • Phosphatidylethanolamines
  • Polymers
  • polyethylene glycol-distearoylphosphatidylethanolamine
  • Polyethylene Glycols