Atypical RNAs in the coelacanth transcriptome

J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):342-51. doi: 10.1002/jez.b.22542. Epub 2013 Oct 30.


Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Fishes / genetics*
  • Molecular Sequence Data
  • RNA / metabolism*
  • RNA Splicing / genetics*
  • RNA, Long Noncoding / metabolism
  • Sequence Analysis, RNA
  • Transcriptome*


  • RNA, Long Noncoding
  • RNA