Impact of genetic variants of apolipoprotein E on lipid profile in patients with Parkinson's disease

Biomed Res Int. 2013;2013:641515. doi: 10.1155/2013/641515. Epub 2013 Sep 24.

Abstract

The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. The APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). The APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Apolipoprotein E3 / blood
  • Apolipoprotein E3 / genetics
  • Apolipoprotein E4 / blood
  • Apolipoprotein E4 / genetics
  • Cholesterol, LDL / blood*
  • Cholesterol, LDL / genetics
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Parkinson Disease / blood*
  • Parkinson Disease / genetics*
  • Polymorphism, Restriction Fragment Length*

Substances

  • Apolipoprotein E3
  • Apolipoprotein E4
  • Cholesterol, LDL