A meta-analysis of four randomised controlled trials of varying methodological quality, involving 304 children aged 1-48 months, showed that Lactobacillus acidophilus LB (LB) reduced the duration of diarrhoea in hospitalised, but not outpatient, children compared with a placebo. The chance of a cure on day three was similar in both groups, but LB increased the chance of cure on day four.
Conclusion: There is limited evidence to recommend LB for treating paediatric diarrhoea.
Keywords: Diarrhoea; Microbiota; Probiotics; RCT; Systematic review.
©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.