Meta-analysis shows limited evidence for using Lactobacillus acidophilus LB to treat acute gastroenteritis in children

Acta Paediatr. 2014 Mar;103(3):249-55. doi: 10.1111/apa.12487. Epub 2013 Dec 20.


A meta-analysis of four randomised controlled trials of varying methodological quality, involving 304 children aged 1-48 months, showed that Lactobacillus acidophilus LB (LB) reduced the duration of diarrhoea in hospitalised, but not outpatient, children compared with a placebo. The chance of a cure on day three was similar in both groups, but LB increased the chance of cure on day four.

Conclusion: There is limited evidence to recommend LB for treating paediatric diarrhoea.

Keywords: Diarrhoea; Microbiota; Probiotics; RCT; Systematic review.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Child
  • Gastroenteritis / therapy*
  • Humans
  • Lactobacillus acidophilus*
  • Probiotics / therapeutic use*
  • Randomized Controlled Trials as Topic