Clinical neurogenetics: stroke

Neurol Clin. 2013 Nov;31(4):915-28. doi: 10.1016/j.ncl.2013.05.001. Epub 2013 Jul 17.


Understanding the genetic architecture of cerebrovascular disease holds promise of novel stroke prevention strategies and therapeutics that are both safe and effective. Apart from a few single-gene disorders associated with cerebral ischemia or intracerebral hemorrhage, stroke is a complex genetic phenotype that requires careful ascertainment and robust association testing for discovery and validation analyses. The recently uncovered shared genetic contribution between clinically manifest stroke syndromes and closely related intermediate cerebrovascular phenotypes offers effective and efficient approaches to complex trait analysis.

Keywords: Cerebrovascular disease; Genetics; Genome-wide association study; Intracerebral hemorrhage; Ischemic stroke; Phenotype; Stroke subtype; White matter hyperintensity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Brain Ischemia / genetics
  • Cerebrovascular Disorders / genetics
  • Humans
  • Risk Factors
  • Stroke / genetics*