Top 10 recent developments in health-related quality of life in patients with systemic lupus erythematosus

Curr Rheumatol Rep. 2013 Dec;15(12):380. doi: 10.1007/s11926-013-0380-9.


Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that has major implications for health-related quality of life (HRQoL). Improvements in the monitoring and management of SLE improves survival; however, improvement of HRQoL remains of paramount importance among these patients. Measurement of HRQoL has been recommended in clinical practice and research including drug development and testing in clinical trials. Both generic and disease specific instruments have been developed to ascertain HRQoL. In an increasingly global collaborative environment, the importance of assessing HRQoL across nations, acknowledgment of their confounders, and limitations of used instruments are critical. Here, we review selected major developments in the past 5 years highlighting: the importance of measuring HRQoL in SLE patients, the benefits and limitations of instruments that exist, and their application in research settings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Confounding Factors, Epidemiologic
  • Cross-Cultural Comparison
  • Health Status Indicators
  • Humans
  • Lupus Erythematosus, Systemic / rehabilitation*
  • Lupus Erythematosus, Systemic / therapy
  • Psychometrics
  • Quality Improvement
  • Quality of Life*
  • Randomized Controlled Trials as Topic