Peripheral T-cell tolerance in hosts with acute myeloid leukemia

Oncoimmunology. 2013 Aug 1;2(8):e25445. doi: 10.4161/onci.25445. Epub 2013 Jul 1.


Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (APCs). Ongoing work focuses on identifying APC subsets that induce T-cell tolerance in AML as well as the precise mechanisms that underlie this phenomenon.

Keywords: AML; APC; anergy; deletion; peripheral tolerance.