Lean people with dysglycemia have a worse metabolic profile than centrally obese people without dysglycemia

Diabetes Technol Ther. 2014 Feb;16(2):91-6. doi: 10.1089/dia.2013.0198. Epub 2013 Nov 4.

Abstract

Aim: This study compared metabolic profiles of Asian Indians with normal waist circumference (WC) and dysglycemia versus those with high WC without dysglycemia.

Subjects and methods: In 2,350 subjects ≥20 years of age from the Chennai Urban Rural Epidemiology Study with full anthropometric and biochemical characterization, high WC was defined as ≥90 cm in males and ≥80 cm in females. Dysglycemia was defined as prediabetes (fasting plasma glucose ≥100 mg/dL and/or 2-h plasma glucose ≥140 mg/dL) or diabetes (fasting plasma glucose ≥126 mg/dL, 2-h plasma glucose ≥200 mg/dL, or treatment for diagnosed diabetes). Coronary artery disease (CAD) was defined as known myocardial infarction or Q waves on electrocardiography. Multivariable logistic regression models were used to explore factors associated with CAD.

Results: Of the subjects, 260 (11.1%) had dysglycemia with normal WC, and 679 (28.9%), had high WC without dysglycemia. Compared with subjects with high WC without dysglycemia, those with dysglycemia/normal WC, adjusted for age, were more likely to be males (P<0.001) and have higher systolic blood pressure (P<0.05), higher serum triglycerides (P<0.001), higher tumor necrosis factor-α (P<0.001), lower high-density lipoprotein cholesterol (P<0.05), and higher prevalence of CAD (6.3% vs. 2.0%; odds ratio 3.25 [95% confidence interval 1.52-6.94]; P=0.002).

Conclusions: Dysglycemia is associated with a worse cardiometabolic profile than central obesity alone.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian Continental Ancestry Group / statistics & numerical data
  • Blood Glucose / metabolism*
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / epidemiology
  • Coronary Artery Disease / prevention & control
  • Cross-Sectional Studies
  • European Continental Ancestry Group / statistics & numerical data
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hyperglycemia / blood*
  • Hyperglycemia / epidemiology
  • Hyperglycemia / ethnology
  • India / epidemiology
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / epidemiology
  • Middle Aged
  • Obesity, Abdominal / blood*
  • Obesity, Abdominal / epidemiology
  • Obesity, Abdominal / ethnology
  • Prevalence
  • Thinness / blood*
  • Thinness / epidemiology
  • Thinness / ethnology

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human