Urease inhibitory activity of ursane type sulfated saponins from the aerial parts of Zygophyllum fabago Linn

Phytomedicine. 2014 Feb 15;21(3):379-82. doi: 10.1016/j.phymed.2013.09.009. Epub 2013 Oct 29.


Five ursane type sulfated saponins have been isolated from the aerial parts of Zygophyllum fabago Linn. (locally called Chashum). The urease inhibitory effects of these compounds have been investigated for the first time as well as their molecular docking studies have also been carried out to check the structure-activity relationship. The IC50 values of these compounds could not be found due to paucity of the samples. The molecular docking studies were performed only for the most active compound mono sodium salt of 3β,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-[β-D-glucopyranosyl] ester (Zygofaboside A; 1).

Keywords: Molecular docking; Sulfated saponins; Urease inhibitory activity; Ursane; Zygophyllum fabago.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Molecular Docking Simulation
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Saponins / chemistry
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Structure-Activity Relationship
  • Urease / antagonists & inhibitors*
  • Zygophyllum / chemistry*


  • 3,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-glucopyranosyl ester
  • Enzyme Inhibitors
  • Plant Extracts
  • Saponins
  • Urease