Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary

Obstet Gynecol. 1986 Feb;67(2):265-8. doi: 10.1097/00006250-198602000-00020.


Eleven previously untreated women with recurrent and/or metastatic granulosa cell tumor of the ovary were treated with cisplatin, vinblastine, and bleomycin in combination. All the six pathological complete responders but one are alive and free of disease at a median follow-up time of 14 months from the start of treatment. Of three partial responders, two died of drug-related toxicity while one, with only microscopic disease at second-look laparotomy, is alive and without evidence of disease at 34 months. Hematologic and nonhematologic toxicity were severe. These promising results require further examination of the activity and the best schedule of treatment with this combination.

MeSH terms

  • Adult
  • Aged
  • Alopecia / chemically induced
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Child
  • Cisplatin / administration & dosage
  • Female
  • Granulosa Cell Tumor / drug therapy*
  • Granulosa Cell Tumor / surgery
  • Hematologic Diseases / chemically induced
  • Humans
  • Hysterectomy
  • Middle Aged
  • Nausea / chemically induced
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / surgery
  • Prospective Studies
  • Vinblastine / administration & dosage


  • Bleomycin
  • Vinblastine
  • Cisplatin