Endoscopic resection for superficial colorectal neoplasia in Italy: a prospective multicentre study

Dig Liver Dis. 2014 Feb;46(2):146-51. doi: 10.1016/j.dld.2013.09.019. Epub 2013 Nov 1.


Background: Since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients.

Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions ≥10mm in size or smaller (if depressed). Outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months.

Results: Overall, 1012 resections in 928 patients were analysed (62.4% sessile polyps, 28.8% laterally spreading tumours, 8.7% depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. En bloc resection was possible in 715/1012 cases (70.7%), whereas piecemeal resection was required in 297 (29.3%). Endoscopically complete excision was achieved in 866 cases (85.6%). Adverse events occurred in 83 (8.2%), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95% CI 1.16-4.26]; p=0.015) and piecemeal endoscopic resection (OR 2.76 [95% CI 1.56-4.87]; p=0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions<20mm, follow-up limited to 1 year.

Conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance.

Keywords: Adverse events; Colorectal neoplasia; Endoscopic resection; Mucosectomy; Outcomes.

Publication types

  • Multicenter Study

MeSH terms

  • Adenoma / surgery*
  • Aged
  • Carcinoma / surgery*
  • Cohort Studies
  • Colonic Polyps / surgery*
  • Colonoscopy / methods*
  • Colorectal Neoplasms / surgery*
  • Female
  • Humans
  • Intestinal Mucosa / surgery*
  • Italy
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local*
  • Prospective Studies
  • Treatment Outcome