Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 3 (11)

Regulatory T-cell Therapy in Transplantation: Moving to the Clinic

Affiliations
Review

Regulatory T-cell Therapy in Transplantation: Moving to the Clinic

Qizhi Tang et al. Cold Spring Harb Perspect Med.

Abstract

Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic efficacy is well documented in animal models. Moreover, human Tregs can be identified, isolated, and expanded in short-term ex vivo cultures so that a therapeutic product can be manufactured at relevant doses. Treg therapy is being planned at multiple transplant centers around the world. In this article, we review topics critical to effective implementation of Treg therapy in transplantation. We will address issues such as Treg dose, antigen specificity, and adjunct therapies required for transplant tolerance induction. We will summarize technical advances in Treg manufacturing and provide guidelines for identity and purity assurance of Treg products. Clinical trial designs and Treg manufacturing plans that incorporate the most up-to-date scientific understanding in Treg biology will be essential for harnessing the tolerogenic potential of Treg therapy in transplantation.

Similar articles

See all similar articles

Cited by 77 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback