Targeted temperature management in survivors of cardiac arrest

Cardiol Clin. 2013 Nov;31(4):637-55, ix. doi: 10.1016/j.ccl.2013.07.010.


Mild therapeutic hypothermia (MTH) results in a significant decrease in mortality and improvement of neurologic outcomes in cardiac arrest (CA) survivors. Cardiologists and intensivists must be acquainted with the indications and technique because MTH is the only proven neuroprotective therapy for CA survivors. CA involves reinstituting meaningful cardiac activity and minimizing secondary neurologic injuries. This article focuses on MTH as the main strategy for post-CA care.

Trial registration: NCT00391469 NCT00827957 NCT00886184 NCT01020916.

Keywords: Cardiac arrest survivors; Hypoxic-ischemic brain injury; Mild therapeutic hypothermia; Neurologic prognosis.

Publication types

  • Review

MeSH terms

  • Body Temperature / physiology
  • Epidemiologic Methods
  • Fever / prevention & control
  • Heart Arrest / therapy*
  • Humans
  • Hypothermia, Induced / methods*
  • Hypoxia-Ischemia, Brain / etiology
  • Hypoxia-Ischemia, Brain / prevention & control
  • Prognosis
  • Rewarming / methods
  • Shivering / physiology
  • Survivors

Associated data