Hypericum perforatum L. preparations for menopause: a meta-analysis of efficacy and safety

Climacteric. 2014 Aug;17(4):325-35. doi: 10.3109/13697137.2013.861814. Epub 2013 Dec 27.


Objective: To compare by meta-analysis the efficacy and adverse events of Hypericum perforatum L. (St. John's Wort), or its combinations, and placebo for menopausal women.

Design: A systematic review and meta-analysis were carried out by searching in Pubmed, Cochrane Library, Embase and the Web of Science database.

Results: Extracts of Hypericum perforatum L. and its combination with herbs were significantly superior to placebo (standard mean difference = -1.08; 95% confidence interval -1.38 to -0.77); extracts of Hypericum perforatum L. proved to be more effective than placebo in the treatment of menopause. Adverse events occurred in 53 (17.4%) patients on Hypericum perforatum L. preparations and 45 (15.4%) patients on placebo (relative risk = 1.16; 95% confidence interval 0.81-1.66).

Conclusion: Extracts of Hypericum perforatum L. have possibly fewer side-effects than placebo for the treatment of menopausal women.


Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Adult
  • Confidence Intervals
  • Depression / drug therapy*
  • Depression / etiology
  • Female
  • Hot Flashes / drug therapy*
  • Hot Flashes / etiology
  • Humans
  • Hypericum*
  • Menopause* / drug effects
  • Menopause* / physiology
  • Menopause* / psychology
  • Middle Aged
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / adverse effects
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Plant Extracts