Slipping past the spindle assembly checkpoint

Nat Cell Biol. 2013 Nov;15(11):1261-3. doi: 10.1038/ncb2876.


Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.

Publication types

  • Comment

MeSH terms

  • Humans
  • M Phase Cell Cycle Checkpoints*
  • Signal Transduction*
  • Spindle Apparatus*