Crosstalk between mTOR complexes

Nat Cell Biol. 2013 Nov;15(11):1263-5. doi: 10.1038/ncb2877.


The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Carcinogenesis*
  • Humans
  • Mechanistic Target of Rapamycin Complex 2
  • Multiprotein Complexes / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / metabolism*


  • Adaptor Proteins, Signal Transducing
  • MAPKAP1 protein, human
  • Multiprotein Complexes
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 2
  • Proto-Oncogene Proteins c-akt