Synthesis of nonadeuterated 1α,25-dihydroxyvitamin D2

J Steroid Biochem Mol Biol. 2014 Oct:144 Pt A:204-6. doi: 10.1016/j.jsbmb.2013.10.025. Epub 2013 Nov 1.

Abstract

An efficient convergent synthesis of nonadeuterated 1α,25-dihydroxyvitamin D2 (1) by Pd(0)-catalyzed coupling between the boronate ester (upper fragment) and the enol triflate (A-ring fragment) is described. This article is part of a Special Issue entitled '16th Vitamin D Workshop'.

Keywords: 1α,25-Dihydroxyvitamin D(2) d(9); Isotopic labelling; Vitamin D(2) analogues synthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcitriol / analogs & derivatives
  • Calcitriol / chemical synthesis*
  • Chemistry Techniques, Synthetic
  • Deuterium / chemistry*
  • Molecular Structure
  • Palladium / chemistry*

Substances

  • Palladium
  • Deuterium
  • Calcitriol