Genetics and biochemistry of resistance to axenomycin in Saccharomyces cerevisiae

S Sora; O Ciferri; G Di Pasquale; G E Magni

doi:10.1007/BF00445695

Genetics and biochemistry of resistance to axenomycin in Saccharomyces cerevisiae

Curr Genet. 1980 Jul;2(1):61-7. doi: 10.1007/BF00445695.

Authors

S Sora¹, O Ciferri, G Di Pasquale, G E Magni

Affiliation

¹ Institute of Genetics, University of Milan, Via Celoria, 10, I-20133, Milano, Italy.

PMID: 24189724
DOI: 10.1007/BF00445695

Abstract

Axenomycin inhibits protein synthesis in vivo and in vitro in Saccharomyces cerevisiae. The antibiotic acts by binding to ribosomes, most probably to the large ribosomal subunit. Mutant strains resistant to axenomycin appear to contain ribosomes that are not inhibited by the antibiotic. The responsible gene has been mapped on the VII chromosome between the centromere and the leu1 gene.