Effects of Coenzyme Q10 Supplementation (300 mg/day) on Antioxidation and Anti-Inflammation in Coronary Artery Disease Patients During Statins Therapy: A Randomized, Placebo-Controlled Trial

Nutr J. 2013 Nov 6;12(1):142. doi: 10.1186/1475-2891-12-142.

Abstract

Background: High oxidative stress and chronic inflammation can contribute to the pathogenesis of coronary artery disease (CAD). Coenzyme Q10 is an endogenous lipid-soluble antioxidant. Statins therapy can reduce the biosynthesis of coenzyme Q10. The purpose of this study was to investigate the effects of a coenzyme Q10 supplement (300 mg/d; 150 mg/b.i.d) on antioxidation and anti-inflammation in patients who have CAD during statins therapy.

Methods: Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery and who were treated with statins for at least one month were enrolled in this study. The subjects (n = 51) were randomly assigned to the placebo (n = 24) and coenzyme Q10 groups (Q10-300 group, n = 27). The intervention was administered for 12 weeks. The concentrations of coenzyme Q10, vitamin E, antioxidant enzymes activities (superoxide dismutase, catalase, and glutathione peroxidase), and inflammatory markers [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6)] were measured in the 42 subjects (placebo, n = 19; Q10-300, n = 23) who completed the study.

Results: The levels of the plasma coenzyme Q10 (P < 0.001) and antioxidant enzymes activities (P < 0.05) were significantly higher after coenzyme Q10 supplementation. The levels of inflammatory markers (TNF-α, P = 0.039) were significantly lower after coenzyme Q10 supplementation. The subjects in the Q10-300 group had significantly higher vitamin E (P = 0.043) and the antioxidant enzymes activities (P < 0.05) than the placebo group at week 12. The level of plasma coenzyme Q10 was significantly positively correlated with vitamin E (P = 0.008) and antioxidant enzymes activities (P < 0.05) and was negatively correlated with TNF-α (P = 0.034) and IL-6 (P = 0.027) after coenzyme Q10 supplementation.

Conclusion: Coenzyme Q10 supplementation at 300 mg/d significantly enhances antioxidant enzymes activities and lowers inflammation in patients who have CAD during statins therapy.

Trial registration: ClinicalTrials.gov Identifier: NCT01424761.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • C-Reactive Protein / metabolism
  • Catalase / blood
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / drug therapy*
  • Dietary Supplements*
  • Dose-Response Relationship, Drug
  • Female
  • Glutathione Peroxidase / blood
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Inflammation / prevention & control*
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects
  • Single-Blind Method
  • Superoxide Dismutase / blood
  • Tumor Necrosis Factor-alpha / blood
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Ubiquinone
  • C-Reactive Protein
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • coenzyme Q10

Associated data

  • ClinicalTrials.gov/NCT01424761