Severe hypoalphalipoproteinaemia in a child with acute post-streptococcal glomerulonephritis (APSGN)

BMJ Case Rep. 2013 Nov 5:2013:bcr2013200952. doi: 10.1136/bcr-2013-200952.

Abstract

We describe a child with acute post-streptococcal glomerulonephritis (APSGN), who developed a very low plasma high-density lipoprotein cholesterol (α-lipoprotein) in association with transient but massive proteinuria. The hypoalphalipoproteinaemia resolved spontaneously concomitant with the remission in proteinuria and the patient had a complete clinical recovery. Urinary loss of apolipoprotein A1 may have contributed to the hypoalphalipoproteinaemia. To our knowledge, this has not been reported previously in APSGN.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents / therapeutic use
  • Child, Preschool
  • Cholesterol, HDL / metabolism*
  • Cholesterol, HDL / urine
  • Follow-Up Studies
  • Glomerulonephritis / etiology*
  • Glomerulonephritis / physiopathology
  • Glomerulonephritis / therapy
  • Humans
  • Male
  • Proteinuria / etiology
  • Proteinuria / physiopathology
  • Rare Diseases
  • Risk Assessment
  • Severity of Illness Index
  • Streptococcal Infections / complications
  • Streptococcal Infections / diagnosis*
  • Streptococcal Infections / drug therapy
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Cholesterol, HDL