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. 2013 Apr;51(4):288-91.

Effect of Vanillin on Lipid Profile in a Model of Hyperlipidemia, a Preliminary Study

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  • PMID: 24195348

Effect of Vanillin on Lipid Profile in a Model of Hyperlipidemia, a Preliminary Study

Yogesh Belagali et al. Indian J Exp Biol. .

Abstract

To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group. Reduction in total cholesterol was significant at 200 and 400 mg/kg doses compared to hyperlipidemic control. The results demonstrate that vanillin at a dose of 200 and 400 mg/kg body weight lowers the serum triglyceride, VLDL-C and total cholesterol level significantly in high fat diet induced hyperlipidemic rats. However there was no significant effect on the lipid profile at 100 mg/kg dose. There were no statistically significant changes in the HDL-C and LDL-C levels at any of the given doses.

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