Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen

J Virol. 1986 Mar;57(3):1168-72. doi: 10.1128/JVI.57.3.1168-1172.1986.

Abstract

We isolated 16 new monoclonal antibodies that recognize large T antigen of simian virus 40 and mapped the epitopes to three distinct regions of the large T antigen. Also, 3 of the 16 recognized the large T antigen of the human papovavirus BKV.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antigens, Polyomavirus Transforming
  • Antigens, Viral, Tumor / analysis
  • Antigens, Viral, Tumor / immunology*
  • Cross Reactions
  • Epitopes / analysis*
  • HeLa Cells
  • Humans
  • Immunoglobulin G / analysis
  • Mice
  • Mice, Inbred BALB C
  • Oncogene Proteins, Viral / analysis
  • Oncogene Proteins, Viral / immunology*
  • Papillomaviridae / immunology
  • Polyomaviridae
  • Protein Denaturation

Substances

  • Antibodies, Monoclonal
  • Antigens, Polyomavirus Transforming
  • Antigens, Viral, Tumor
  • Epitopes
  • Immunoglobulin G
  • Oncogene Proteins, Viral