Abstract
We isolated 16 new monoclonal antibodies that recognize large T antigen of simian virus 40 and mapped the epitopes to three distinct regions of the large T antigen. Also, 3 of the 16 recognized the large T antigen of the human papovavirus BKV.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology*
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Antigens, Polyomavirus Transforming
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Antigens, Viral, Tumor / analysis
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Antigens, Viral, Tumor / immunology*
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Cross Reactions
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Epitopes / analysis*
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HeLa Cells
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Humans
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Immunoglobulin G / analysis
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Mice
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Mice, Inbred BALB C
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Oncogene Proteins, Viral / analysis
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Oncogene Proteins, Viral / immunology*
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Papillomaviridae / immunology
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Polyomaviridae
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Protein Denaturation
Substances
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Antibodies, Monoclonal
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Antigens, Polyomavirus Transforming
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Antigens, Viral, Tumor
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Epitopes
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Immunoglobulin G
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Oncogene Proteins, Viral