Neovascular glaucoma after helium ion irradiation for uveal melanoma

Ophthalmology. 1986 Feb;93(2):189-93. doi: 10.1016/s0161-6420(86)33770-9.


Neovascular glaucoma developed in 22 of 169 uveal melanoma patients treated with helium ion irradiation. Most patients had large melanomas; no eyes containing small melanomas developed anterior segment neovascularization. The mean onset of glaucoma was 14.1 months (range, 7-31 months). The incidence of anterior segment neovascularization increased with radiation dosage; there was an approximately three-fold increase at 80 GyE versus 60 GyE of helium ion radiation (23% vs. 8.5%) (P less than 0.05). Neovascular glaucoma occurred more commonly in larger tumors; the incidence was not affected by tumor location, presence of subretinal fluid, nor rate of tumor regression. Fifty-three percent of patients had some response with intraocular pressures of 21 mmHg or less to a combination of antiglaucoma treatments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anterior Eye Segment / blood supply*
  • Dose-Response Relationship, Radiation
  • Glaucoma / etiology*
  • Glaucoma / therapy
  • Helium / therapeutic use*
  • Humans
  • Melanoma / radiotherapy*
  • Neovascularization, Pathologic / etiology*
  • Neovascularization, Pathologic / therapy
  • Radiation Injuries*
  • Uveal Neoplasms / radiotherapy*


  • Helium