Immune response in severe infection: could life-saving drugs be potentially harmful?

Maja Surbatovic; Jasna Jevdjic; Milic Veljovic; Nada Popovic; Dragan Djordjevic; Sonja Radakovic

doi:10.1155/2013/961852

Immune response in severe infection: could life-saving drugs be potentially harmful?

ScientificWorldJournal. 2013 Sep 30:2013:961852. doi: 10.1155/2013/961852. eCollection 2013.

Authors

Maja Surbatovic¹, Jasna Jevdjic, Milic Veljovic, Nada Popovic, Dragan Djordjevic, Sonja Radakovic

Affiliation

¹ Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia ; Faculty of Medicine of the Military Medical Academy, University of Defense, Crnotravska 17, 11000 Belgrade, Serbia.

Abstract

Critically ill patients suffer a high rate of nosocomial infection with secondary sepsis being a common cause of death. Usage of antibiotics and catecholamines is often necessary, but it can compromise complex immune response to infection. This review explores influence of these life-saving drugs on host immune response to severe infection.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / therapeutic use
Catecholamines / adverse effects
Catecholamines / therapeutic use
Critical Illness*
Drug-Related Side Effects and Adverse Reactions
Humans
Infections / drug therapy
Infections / immunology*

Substances

Anti-Bacterial Agents
Catecholamines