Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 4 (4), 108-12

Non-dietary Forms of Treatment for Adult Celiac Disease

Affiliations
Review

Non-dietary Forms of Treatment for Adult Celiac Disease

Hugh James Freeman. World J Gastrointest Pharmacol Ther.

Abstract

At present, treatment for celiac disease includes a strict gluten-free diet. Compliance, however, is difficult and gluten-free food products are costly, and, sometimes very inconvenient. A number of potential alternative measures have been proposed to either replace or supplement gluten-free diet therapy. In the past, non-dietary forms of treatment were used (e.g., corticosteroids) by some clinicians, often to supplement a gluten-free diet in patients that appeared to be poorly responsive to a gluten-free diet. Some of new and novel non-dietary measures have already advanced to a clinical trial phase. There are still some difficulties even if initial studies suggest a particularly exciting and novel form of non-dietary treatment. In particular, precise monitoring of the response to these agents will become critical. Symptom or laboratory improvement may be important, but it will be critical to ensure that ongoing inflammatory change and mucosal injury are not present. Therapeutic trials will be made more difficult because there is already an effective treatment regimen.

Keywords: Adult celiac disease; Gluten-free diet; Immunotherapy; Non-dietary treatment of celiac disease; Protease; Tight junction inhibition; Vaccination.

Similar articles

  • Monitoring Nonresponsive Patients Who Have Celiac Disease
    N Krauss et al. Gastrointest Endosc Clin N Am 16 (2), 317-27. PMID 16644460. - Review
    Because of the wide variations in the clinical presentation of celiac disease and because treatment exists that is effective in most cases, screening of the general popul …
  • Future Treatment Strategies for Celiac Disease
    K Lindfors et al. Expert Opin Ther Targets 16 (7), 665-75. PMID 22620264. - Review
    Phase II clinical trials are already ongoing to test the efficacy of novel alternative treatments for celiac disease. Before any of the candidates can enter Phase III tri …
  • Novel Treatments for Celiac Disease: Glutenases and Beyond
    K Kaukinen et al. Dig Dis 33 (2), 277-81. PMID 25925935. - Review
    Currently, the only effective treatment for celiac disease is a strict lifelong gluten-free diet. However, gluten-free dieting is restrictive, difficult to maintain and n …
  • Current and Emerging Therapy for Celiac Disease
    GK Makharia. Front Med (Lausanne) 1, 6. PMID 25705619. - Review
    At present, strict and lifelong gluten-free diet is the only effective treatment for celiac disease. Even small amounts of gluten (50 mg/day) can be immunogenic; therefor …
  • Emerging Drugs for Celiac Disease
    HJ Freeman. Expert Opin Emerg Drugs 20 (1), 129-35. PMID 25494908. - Review
    Most recent published double-blind, placebo-controlled clinical trials have focused on an orally administered recombinant glutenase (ALV003) showing significant but limit …
See all similar articles

Cited by 5 PubMed Central articles

Feedback