Effect of fasting with two meals on BMI and inflammatory markers of metabolic syndrome

Pak J Biol Sci. 2012 Mar 1;15(5):255-8. doi: 10.3923/pjbs.2012.255.258.


The metabolic syndrome has been recognized as a proinflammatory state and inflammatory markers are associated with an increased risk for subsequent cardiovascular disease and type 2 diabetes. The aim of this clinical trial study was to evaluate the effect of Ramadan fasting on High-sensitive C-reactive Protein (hs-CRP) and fibrinogen levels in metabolic syndrome. Sixty five male with metabolic syndrome who were admitted to Hospital were selected for the study. Waist circumference, BMI, FPG, HDL-C, TG, fibrinogen and hs-CRP were evaluated before and after month of Ramadan. The duration of study was thirty days. The dietary intake was estimated by 24 h recall before and after fasting. Metabolic syndrome was diagnosed using the ATP III criteria. FPG, HDL-C, fibrinogen, hs-CRP, BMI and waist circumference were decreased significantly after study (p = 0.005, p = 0.002, p = 0.02, p = 0.01, p = 0.01, p = 0.01, respectively). There was no change in serum TG level (p = 0.21). Simple linear regression analysis demonstrated that after fasting, hs-CRP was related to waist circumference and BMI (r = 0.388, p = 0.01 and r = -0.439, p = 0.02, respectively). Change in the number and timing of meals and portioning the entire intake into two without changing the total energy consumption may have beneficial effects on anthropometry measures and inflammatory markers of metabolic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index*
  • Fasting*
  • Humans
  • Inflammation / blood*
  • Male
  • Metabolic Syndrome / blood*
  • Middle Aged