The Association Between the Neutrophil-to-Lymphocyte Ratio and the Presence of Ventricular Premature Contractions in Young Adults

Clin Appl Thromb Hemost. 2015 Jul;21(5):475-9. doi: 10.1177/1076029613509478. Epub 2013 Nov 6.


Inflammation has recently emerged in the pathogenesis of several cardiovascular disorders, including arrhythmias. The neutrophil-lymphocyte ratio (NLR) is a simple marker for the assessment of inflammatory status. Therefore, we aimed to investigate the relationship between the NLR and the ventricular premature contraction (VPC) existence. Patients aged between 18 and 40 years who were referred to the cardiology clinic were enrolled in the study. All patients' complete blood counts and 24-hour Holter recordings were analyzed. The NLR was higher within the VPC group compared to the control group (P < .001). According to the NLR tertiles, VPCs were more common in the higher NLR tertile (P < .001). A cutoff point of 1.80 for the NLR had 71% sensitivity and 60% specificity in predicting VPC in apparently healthy individuals. After multivariate analysis, only the NLR remained significant predictor of presence of VPC. In conclusion, the NLR is independently and significantly associated with VPC existence.

Keywords: inflammation; neutrophil-to-lymphocyte ratio; ventricular premature contraction.

MeSH terms

  • Adolescent
  • Adult
  • Arrhythmias, Cardiac / blood*
  • Cardiovascular Diseases / blood*
  • Female
  • Humans
  • Inflammation / blood*
  • Inflammation / pathology
  • Lymphocytes / metabolism*
  • Male
  • Neutrophils / metabolism*
  • Retrospective Studies
  • Ventricular Premature Complexes / blood*
  • Young Adult