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Comment
. 2013 Nov 7;122(19):3385-7.
doi: 10.1182/blood-2013-08-524124.

GATA3 Risk Alleles Are Associated With Ancestral Components in Hispanic Children With ALL

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Free PMC article
Comment

GATA3 Risk Alleles Are Associated With Ancestral Components in Hispanic Children With ALL

Kyle M Walsh et al. Blood. .
Free PMC article

Figures

Figure 1
Figure 1
Association of SNPs in the GATA3 locus with B-ALL risk among Hispanic children, by subtype. Association of 68 directly genotyped SNPs (black) and 477 imputed SNPs (gray) with B-ALL risk, adjusted for the first 5 principal components. Circles denote associations for B-ALL cases compared with controls. Triangles denote associations for nonhyperdiploid B-ALL cases without TEL-AML1 fusion compared with controls. Haplotype structure in the Hispanic sample appears below gene names, with darker shading indicating higher R2 values and greater correlation between SNP genotypes. The strongest association in the Hispanic samples is at rs1271899 located in haplotype block 5. The strongest association from Migliorini et al, rs3824662, is located between blocks 5 and 6 and is weakly but significantly linked to rs1271899 (R2, 0.10; P < .0001).

Comment on

  • Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
    Migliorini G, Fiege B, Hosking FJ, Ma Y, Kumar R, Sherborne AL, da Silva Filho MI, Vijayakrishnan J, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE, Sheridan E, Thompson P, Hoffmann P, Nöthen MM, Mühleisen TW, Eisele L, Zimmermann M, Bartram CR, Schrappe M, Greaves M, Stanulla M, Hemminki K, Houlston RS. Migliorini G, et al. Blood. 2013 Nov 7;122(19):3298-307. doi: 10.1182/blood-2013-03-491316. Epub 2013 Aug 30. Blood. 2013. PMID: 23996088

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