Androgen receptor signaling fuels DNA repair and radioresistance in prostate cancer

Cancer Discov. 2013 Nov;3(11):1222-4. doi: 10.1158/2159-8290.CD-13-0679.


Successful treatment by genotoxic modalities including radiotherapy is commonly hampered by treatment resistance in advanced cancers. Two new studies now reveal that androgen receptor signaling transcriptionally upregulates a large subset of DNA repair genes, thereby enhancing the repair capacity and promoting radioresistance of prostate cancer. These results provide a mechanistic rationale for a combined treatment by ionizing radiation and androgen deprivation therapy.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA Damage / radiation effects*
  • DNA Repair*
  • DNA-Activated Protein Kinase / metabolism*
  • Drug Resistance, Neoplasm / genetics*
  • Humans
  • Male
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms, Castration-Resistant / drug therapy*
  • Receptors, Androgen / metabolism*


  • AR protein, human
  • Receptors, Androgen
  • DNA-Activated Protein Kinase