The intertwined roles of transcription and repair proteins

Mol Cell. 2013 Nov 7;52(3):291-302. doi: 10.1016/j.molcel.2013.10.018.


Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to repair DNA lesions that could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point to an even more direct function of DNA repair complexes as coactivators of transcription and the unexpected role of "scheduled" DNA damage/repair at gene promoters. Paradoxically, spontaneous DNA double-strand breaks also induce ectopic transcription that is essential for repair. Thus, transcription, DNA damage, and repair may be more physically and functionally intertwined than previously appreciated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA / genetics*
  • DNA Breaks, Double-Stranded
  • DNA Damage / genetics
  • DNA Repair / genetics*
  • Genomic Instability
  • Humans
  • Promoter Regions, Genetic
  • Proteins / genetics*
  • Transcription, Genetic*


  • Proteins
  • DNA