PAF makes it EZ(H2) for β-catenin transactivation

Mol Cell. 2013 Oct 24;52(2):157-8. doi: 10.1016/j.molcel.2013.10.008.


In this issue of Molecular Cell, Park and colleagues (Jung et al., 2013) show that PAF (PCNA-associated factor) binds to and hyperactivates transcriptional function of β-catenin in colon cancer cells by recruiting EZH2 to the coactivator complex. PAF-β-catenin and PAF-PCNA interactions are competitive, raising the question of whether β-catenin might regulate PCNA-dependent DNA replication and repair.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carrier Proteins / metabolism*
  • DNA-Binding Proteins
  • Enhancer of Zeste Homolog 2 Protein
  • Humans
  • Polycomb Repressive Complex 2 / metabolism*
  • Wnt Signaling Pathway*
  • beta Catenin / metabolism*


  • Carrier Proteins
  • DNA-Binding Proteins
  • PCLAF protein, human
  • beta Catenin
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2