Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders

Cell Rep. 2013 Nov 14;5(3):567-72. doi: 10.1016/j.celrep.2013.10.003. Epub 2013 Nov 7.


Although growing evidence indicates atypical long-distance connectivity in autism spectrum disorder (ASD), much less is known about local connectivity, despite conjectures that local overconnectivity may be causally involved in the disorder. Using functional connectivity MRI and graph theory, we found that local functional connectivity was atypically increased in adolescents with ASD in temporo-occipital regions bilaterally. Posterior overconnectivity was found to be associated with higher ASD symptom severity, whereas an ASD subsample with low severity showed frontal underconnectivity. The findings suggest links between symptomatology and local connectivity, which vary within the autism spectrum.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain / physiopathology*
  • Brain Mapping / methods*
  • Child Development Disorders, Pervasive / etiology
  • Child Development Disorders, Pervasive / physiopathology*
  • Disease Progression
  • Female
  • Humans
  • Male
  • Nerve Net / physiopathology